Inflame-aging

The following image was designed to illustrate how inflammatory foods accelerate the aging process. The dietary and supplement approach in the Deflaming Guidelines are designed to blunt the uncontrolled chronic inflammation of aging and serve as a method to promote health and longevity.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

While it might read like a made-up term, inflamm-aging or inflammaging, are accepted terms in the scientific literature. The term “inflammaging” was coined for the purpose of describing the newly appreciated observation that a chronic subclinical inflammatory state will lead to diseases associated with aging. Inflammaging is initially quite, subclinical:

Is inflammaging an auto[innate]immunity subclinical syndrome?                    http://www.ncbi.nlm.nih.gov/pubmed/17173699

 Depending on our genetic disposition for disease expression, any number of diseases are possible, including cardiovascular disease, cancer, chronic pain, arthritis, osteoporosis, and neurodegenerative diseases. The link below describes this relationship to Alzheimer’s disease:

Inflammaging as a prodrome to Alzheimer’s disease                                        http://www.ncbi.nlm.nih.gov/pubmed/19014446

 Dr. Claudio Franceschi, who is credited with coining the term “inflammaging,” also tells us that we can “ANTI-inflammage” (1). The best available evidence indicates that the following factors promote health aging or “anti-inflammaging”:

1. Maintaining proper body weight. Make your goal to achieve and maintain your high school or college weight; that is, whatever you weighed prior to the addition of excess body fat.

2. Exercise regularly – that means every day do something for 30-60 minutes.

3.Eat anti-inflammatory foods to reach and maintain your ideal body weight. This means we need to moderately reduce our caloric intake and make sure that the foods we choose are anti-inflammatory.

4. Take anti-inflammatory supplements – the Basic Health Promotion supplement program contains a multivitamin (2,3), magnesium (4), omega-3 fish oil (5,6), and vitamin D (7), all of which have been linked to reduced inflammation and healthy aging. Advanced Health Promotion supplement program contains the addition of probiotics (8), coenzyme Q10 (9), and botanicals/spices (10,11), all of which are supportive of healthy aging. 

 

References

1. Franceschi C et al. Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Devel. 2007;128:92-105.

2. Ames BN. Increasing longevity by tuning up metabolism. To maximize human health, lifespan, scientists must abandon outdated models of micronutrients. EMBO Rep. 2005;6(S1):S20-S24.

3. Xu Q et al. Multivitamin use and telomere length in women. Am J Clin Nutr. 2009;89:1857-63.

4. Killilea DW, Maier JA. A connection between magnesium deficiency and aging: new insights from cellular studies. Mag Res. 2008;21(2):77-82.

5. Palacios-Pelaez R et al. Omega-3 essential fatty acids modulate initiation and progression of neurodegenerative disease. Mol Neurobiol. 2010;41:367-74.

6. Simopoulos AP. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular and other chronic diseases. Exp Biol Med. 2008; 233:674-88.

7. Zhu H et al. Increased telomerase activity and vitamin D supplementation in overweight African Americans. Inter J Obesity. 2011;1-5. doi:10.1038/ijo.2011.197

8. Ottaviani E et al. Gut microbiota as a candidate for lifespan extension: an ecological/evolutionary perspective targeted on living organisms as metaorganisms. Biogerontology. 2011;12:599–609.

9. Linnane AW, Zhang C, Yarovaya N et al. Human aging and global function of coenzyme Q10. Ann N Y Acad Sci. 2002; 959:396-411.

10. Aggarwal BB, Shishodia S. Suppression of the nuclear factor-{kappa}B activation pathway by spice-derived phytochemicals: reasoning for seasoning. Ann N Y Acad Sci. 2004; 1030:434-41.

11. Goel A, Kunnumakkara AB, Aggarwal BB. Curcumin as “curecumin”: from kitchen to clinic. Biochem Pharmacol. 2008; 75:787-809.